DELETION 7q ABNORMALITY IN A CHILDHOOD PRE B ALL: A CASE REPORT AND REVIEW OF LITERATURE
Aim: In childhood and adult Acute myeloid leukemia and Myelodysplastic syndrome chromosome 7 aberrations are not an uncommon.But in childhood ALL it is rarely seen.In this case we identified a rare cytogenetic aberration in a girl with Precursor B cell acute lymphoblastic leukemia.
Method: Ten and a half year old girl presented with complaints of fever for two weeks and generalized body swelling for ten days.She was anaemic,tachycardia with mild hepatosplenomegaly.She had raised TLC-67×109/L with 52% blasts.MLL gene and bcr-abl were negative.
Result: Our patient cytogenetic analysis showed deletion 7q22-34.
Conclusion: Studies have shown that the long arm of 7q from 7q22-q36 has many important tumor suppressor genes located on it.Thus its deletion results in increased leukemogenesis propensity.It will be interesting to find any interconnection between myeloid and lymphoid clones and chromosome 7 abnormalities.
Keywords: Pre B ALL, Chromosome 7, Deletion 7q22-34, Tumor suppressor gene, Leukemogenesis, Cytogenetic.