DE NOVO DELETION 17P

DE NOVO DELETION 17P (DEL17P) IN AN ADULT T-CELL PROLYMPHOCYTICLEUKAEMIA AS A RARE PRESENTATION

ABSTRACT:

T-Cell Prolymphocytic leukemia is a rare and an aggressivelymphoproliferative disease which is unresponsive to conventional chemotherapy.We present a case of 72 years old female hospitalized in July 2018 in National Institute of Blood diseases and BMT, Karachi, Pakistan, having lymphadenopathy, splenomegaly, leucocytosis with lymphocytosis, thrombocytopenia and peripheral smear showed predominant population of mature looking lymphocytes. Immunophenotyping shows CD45 (+), CD3(+), CD4(+), CD5(+), ZAP70(+), CD38(+)*, CD25(+)* and negative CD19, CD20, CD10, CD11c, CD8, FMC, Kappa & Lambda and cytogenetics by FISH showed del17 p53 in 35% of interphase nuclei. In patients of T-PLL, del 17 p53 has never been reported previously.

KEYWORD

del17p, T-cell, Prolymphocytic, Leukemia, Lymphoproliferative, CLL.

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